Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis
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چکیده
منابع مشابه
Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis
Two-pore channels (TPC1, 2, and 3) are recently identified endolysosmal ion channels, but remain poorly characterized. In this study, we show for the first time a role for TPC1 in cytokinesis, the final step in cell division. HEK 293 T-REx cells inducibly overexpressing TPC1 demonstrated a lack of proliferation accompanied by multinucleation and an increase in G2/M cycling cells. Increased TPC1...
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ژورنال
عنوان ژورنال: Channels
سال: 2015
ISSN: 1933-6950,1933-6969
DOI: 10.4161/19336950.2014.978676